Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex
ABSTRACT Human health is threatened by bacterial infections that are increasingly resistant to multiple drugs.A recently emerged strategy consists of disarming pathogenic bacteria by targeting and blocking their virulence factors.The type VI secretion system (T6SS) is a widespread secretion nanomachine encoded and employed by pathogenic strains to